Reach for leaderless replication when availability and write throughput matter more than reading your own writes instantly. Shopping carts, sensor data, activity feeds, session stores, and event logging all tolerate brief disagreement well. If a cart line item shows up a second late, nobody cares; if the checkout page is down, you lose money.
The big trade-off is consistency. Quorums give you strong-ish reads only on average. With concurrent writes to the same key, two replicas can end up with conflicting values, and the database has to resolve them. Cassandra defaults to last-write-wins by timestamp, which can silently drop data; Riak can keep both versions as siblings and hand the conflict back to your application to merge.
You also lose easy transactions and ordering guarantees across keys. Sloppy quorums, where a write lands on whatever N nodes are reachable rather than the canonical N, boost availability further but can return stale reads even when W + R > N. Plan for clock skew, plan for conflict resolution up front, and do not assume a successful quorum write means every replica is current.